Piperonyl Butoxide (PBO, Butacide, Butocide, '5-[2-(2-butoxyethoxy)ethoxymethyl]-6-propyl-1,3-benzodioxole', CAS#51-03-6) is an organic compound used as pesticide synergist, especially for pyrethrins, pyrethroids, and rotenone. It does not by itself have pesticidal properties. However, when added to insecticide mixtures, typically pyrethrins, pyrethroid, and carbamate insecticides, their potency is increased considerably. It is a semisynthetic derivative of safrole.

Piperonyl butoxide (PBO) is an insecticide synergist. It acts by protecting the co- applied insecticide (e.g. pyrethrins, pyrethroids and other pesticides) from metabolic attack thus allowing them to reach their biochemical targets. Since piperonyl butoxide inhibits an enzyme system which is catalysing oxidative processes in living systems, it also has an intrinsic toxic potential to arthropods. It is widely used in combination with pyrethrins, pyrethroids and other pesticides, in public health, household and human and veterinary medicinal products, agriculture, stored product protection, home and garden, etc. against a variety of flying and crawling arthropod species, e.g. mosquitoes, houseflies, cockroaches, storage pests, mites, moths, ticks, lice, etc.

Piperonyl butoxide is a potent inhibitor of cytochrome P450 enzymes, which detoxify insecticides for many pests. Therefore, inhibiting the P450s allows higher unmetabolised systemic concentrations of the insecticide (such as pyrethroid) to remain within the target animal for a longer period.

1. Avoid mixture with food and forage, and avoid reach of children.
2. Use respirator and glove when handling, clean completely with soap and water when splashed into skin.
3. Destroy and bury waste drum or dip it into alkali liquid for several days for recycling uses.
4. Storage in dry, cold area and avoid light.